FUNDAMENTALS OF BIOMEMS AND MEDICAL MICRODEVICES PDF
Microfluidic devices have found applications in several fields of engineering, namely biomedical, chemical and mechanical engineering (Nguyen and Wereley ). Bio-MEMS is an abbreviation for biomedical (or biological) micro-electro-mechanical systems [5,6]. Interest in MEMS for. Sample Pages pdf-favicon. Spie Press Book. Fundamentals of BioMEMS and Medical Microdevices. Author(s): Steven S. Saliterman. Fundamentals of BioMEMS and Medical Microdevices Steven S. Saliterman. BioMEMS is a science that includes more than simply finding biomedical applications for microelectromechanical systems devices. It brings together the creative talents of electrical, mechanical, optical, and.
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fundamentals of biomems and pdf. Fundamentals of biomems and medical microdevices pdf. BioMEMS devices are as important to the future of. “introduction to biomems & medical microdevices” prof. steven s. saliterman microdevices pdf or fundamentals of biomems and medical microdevices pdf info . fundamentals of biomems and medical microdevices fundamentals of biomems and pdf. wildlifeprotection.info is a platform for academics to share research papers.
This will allow small companies to enter the market and focus on one or more aspects of more complex systems. United States and foreign patents help recoup investments in bioMEMS devices by allowing a company to develop, manufacture, and market a new device, or license the technology as they see fit.
Investors must be aware that the road for a newly patented device to market is a difficult and expensive journey not unlike the development of a new medication. There may be biocompatibility issues to resolve, clinical trials to perform, and Federal Drug Administration FDA requirements to satisfy. In the end someone will need to pay for the new technology, including facilities that buy bioMEMS-based equipment, and the patients who require evaluation and therapy.
New devices intended for medical care will require advocacy from the medical community and demonstration of superiority over existing methods.
This book is the first dedicated to bioMEMS and medical microdevice training, and is suitable for a single semester course for upper senior and graduate students, or as an introduction to others interested or already working in the field. Topics include 1 microfabrication of silicon, glass, and polymer devices; 2 microfluidics and electrokinetics; 3 sensors, actuators, and drug-delivery systems; 4 micro-total- analysis-systems mTAS and lab-on-a-chip devices LOC ; 5 an introduction to clinical laboratory medicine; 6 detection and measuring systems; 7 genomics, proteomics, DNA, and protein microarrays; 8 emerging applications in medicine, research, and homeland security; 9 packaging, power systems, data communication, and RF safety; and 10 biocompatibility, FDA guidance, and ISO biological evaluations.
The book is written to appeal to the diversity of training and background of its readers, and includes introductory material, advanced concepts, and current research. The foundations for conceiving, designing, and applying bioMEMS and medical microdevices at both the research and clinical level are addressed.
An extensive glossary covers both the engineering and healthcare terminology.
I am very appreciative of the staff at SPIE, including its editorial staff and reviewers, and of all the others who made this book possible. I am also grateful to my students and colleagues, and for the opportunity to lecture on this subject in the Department of Biomedical Engineering at the University of Minnesota, under the leadership of Robert Tranquillo.
There are many individuals who through the years have provided me with the necessary background and inspiration to complete this book, and I would like to express my sincere gratitude. I would also like to thank the many authors and investigators whose works I have relied on in completing this book.
Comments and suggestion for future editions are always welcome. The basic scheme involves two perpendicular flow conduits separated by an impermeable elastomeric membrane at their intersection.
Controlled air flow passes through one conduit while the process fluid passes through the other. A pressure gradient between the two conduits, which is tuned by changing the control air flow rate, causes the membrane to deform and obstruct flow in the process channel. Ice Valves[ edit ] Diagram of an ice valve with Peltier cooling element. Ice valves operate by transporting heat away from a single portion of a flow channel, causing the fluid to solidify and stop flow through that region.
Thermoelectric TE units are used to transport heat away from the plug. Current state of the art ice valve technology features short closing times 0. Prefabricated Valves[ edit ] Prefabricated mechanical screw valves and solenoid valves require no advanced microfabrication processes and are easy to implement in soft substrate materials like PDMS.
Micro-scale Mixing[ edit ] Despite the fact that diffusion times are significantly higher in microfluidic systems due to small length scales, there are still challenges to removing concentration gradients at the time scales required for microfluidic technologies.
Laminar flow with axial concentration gradients flows in, and laminar flow with diminished concentration gradients flows out. Sonication is often employed to provide local mixing of streams through the generation of ultra-high energy acoustics. The primary mechanism of cell lysis by sonication is intense local heating and shear forces.
This technology is in its infancy, however, and it is still not able to be used beyond a few, limited applications. The goals of genomic and proteomic microarrays are to make high-throughput genome analysis faster and cheaper, as well as identify activated genes and their sequences. Oligonucleotide chips[ edit ] Oligonucleotide chips are microarrays of oligonucleotides.
Fundamentals of BioMEMS and Medical Microdevices
Conversely, green dots mean that the corresponding gene was expressed at a higher level in the untreated sample. Yellow dots, as a result of the overlap between red and green dots, mean that the corresponding gene was expressed at relatively the same level in both samples, whereas dark spots indicate no or negligible expression in either sample.Topics include microfabrication of silicon, glass, and polymer devices, microfluidics and electrokinetics, sensors, actuators, and drug-delivery systems, micro-total-analysis systems and lab-on-a-chip devices, detection and measuring systems, genomics, proteomics, DNA, and protein microarrays, emerging applications in medicine, research, and homeland security, and packaging, biocompatibility, and ISO testing.
One inexpensive method of producing valves with fast actuation times and variable flow restriction is multilayer soft lithography MSL. Although perhaps not an ideal term, since electromechanical evokes an image of electrically driven coils, solenoids, and machined parts, it has caught on to encompass some of the most interesting new technologies today.
Designing, modeling, and fabricating medical microdevices will increase enormously in the next ten years, and the need for people involved in this activity to communicate their ideas, needs, and capabilities requires specialized training that bridges diverse backgrounds, and introduces the terminology and potential of the field.
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This allows the production of disposable or single-use chips for improved ease of use and reduced probability of biological cross contamination , as well as rapid prototyping   Microfluidic devices consume much smaller amounts of reagents , can be made to require only a small amount of analytes for chemical detection, require less time for processes and reactions to complete, and produces less waste than conventional macrofluidic devices and experiments  Appropriate packaging of microfluidic devices can make them suitable for wearable applications, implants , and portable applications in developing countries  An interesting approach combining electrokinetic phenomena and microfluidics is digital microfluidics.
It brings together the creative talents of electrical, mechanical, optical, and chemical engineers, materials specialists, clinical laboratory scientists, and physicians. There were gaps in the metal layer above the planar oxide layer, which is common for many bioMEMS and biochips. This work includes microsensing, microactuation, microassaying, micromoving, and microdelivery.
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