BLUE BRAIN IEEE PAPER PDF
This paper presents a literature survey on the Blue Brain technology that promptly answers all these sparkling questions. Scientists today are in research to take. Abstract: The Blue Brain Project began in July as a collaboration between Professor Henry Markram from the Brain Mind Institute at the EPFL (Ecole Polytechnique Fédérale de Lausanne) and IBM (International Business Machines), aimed at modelling the neocortical column. BLUE BRAIN in IEEE wildlifeprotection.info - Download as Word Doc .doc), PDF File . pdf), Raymond Kurzweil recently provided an interesting paper on this topic.
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Blue Brain IEEE - Download as Word Doc .doc /.docx), PDF File .pdf), Text File A research paper published by the BBP team in describes the following. Request PDF on ResearchGate | “The Blue Brain Project” | The Blue Brain Conference Paper in Conference proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. PDF | Artificial Intelligence | ResearchGate, the professional network for scientists . Download full-text PDF .. Hil, sean: Markram Henry, International conference of IEEE Review paper on Blue Brain Technology.
Scientists today are in research to take artificial intelligence to a level beyond everything, to create a virtual brain that could think, react, make decisions and also keep everything in some form of memory to do everything that a normal human brain can. To achieve this, the main approach is to upload an actual brain in a virtual brain.
So that even after death the person's conscience would be able to function exactly as a normal brain in the form of a machine. If this simulation results in a success, the modeling would extend to different parts of the brain and make it function with all the abilities of a natural brain, thereby eliminating the chances of any brain malfunctions such as psychiatric disorders like depression and autism, which are possible in the normal brain.
IBM names this project as the 'Blue Brain' project. Published in: Persistent Link: Need Help? Shown in fig. A different supercomputer is used for this computationally intensive task. The visualization of the neurons shapes is a challenging task given the fact that a column of 10, neurons rendered in high quality mesh accounts for essentially 1 billion triangles for which about GB of management data is required. Simulation data with a resolution of electrical compartments for each neuron accounts for another GB.
A visual interface makes it possible to quickly identify areas of interest that can then be studied more extensively using further simulations Fig. Simulating The Microcircuit Once the microcircuit is built, the exciting work of making the circuit function can begin. All the processors of the Blue Gene are pressed into service, in a massively parallel computation solving the complex mathematical equations that govern the electrical activity in each neuron when a stimulus is applied.
As the electrical impulse travels from neuron to neuron, the results are communicated via interprocessor F.
Chayan Shah1, Pawan Kumar2
Whole Brain Simulations The main limitations for digital computers in the simulation of biological processes are the extreme temporal and spatial resolution demanded by some biological processes, and the limitations of the algorithms that are used to model biological processes. If each atomic collision is simulated, the most powerful supercomputers still take days to simulate a microsecond of protein folding, so it is, of course, not possible to simulate complex biological systems at the atomic scale.
However, models at higher levels, such as the molecular or cellular levels, can capture lower-level processes and allow complex large-scale simulations of biological processes. However, simulating neurons embedded in microcircuits, microcircuits embedded in brain regions, and brain regions embedded in the whole brain as part of the process of understanding the emergence of complex behaviors of animals is an inevitable progression in understanding brain function and dysfunction, and the question is whether whole-brain simulations are at all possible.
Gathering And Testing Years Of Data The most immediate benet is to provide a working model into which the past years knowledge about the microstructure and workings of the neocortical column can be gathered and tested.
The Blue Column will therefore also produce a virtual library to explore in 3D the microarchitecture of the neocortex and access all key research relating to its structure and function. In the same way that the neuron is the elementary cell for computing in the brain, the NCC is the elementary network for computing in the neocortex. Creating an accurate replica of the NCC which faithfully reproduces the emergent electrical dynamics of the real microcircuit, is an absolute requirement to revealing how the neocortex processes, stores and retrieves information.
Blue Brain PDF Abstract
A Novel Tool For Drug Discovery For Brain Disorders Understanding the functions of different elements and pathways of the NCC will provide a concrete foundation to explore the cellular and synaptic bases of a wide spectrum of neurological and psychiatric diseases. The impact of receptor, ion channel, cellular and synaptic decits could be tested in simulations and the optimal experimental tests can be determined. A Global Facility A software replica of a NCC will allow researchers to explore hypotheses of brain function and dysfunction accelerating research.
Simulation runs could determine which parameters should be used and measured in the experiments. An advanced 2D, 3D and 3D immersive visualization system will allow imaging of many aspects of neural dynamics during processing, storage and retrieval of information.
Such imaging experiments may be impossible in reality or may be prohibitively expensive to perform. A Foundation For Whole Brain Simulations With current and envisageable future computer technology it seems unlikely that a mammalian brain can be simulated with full cellular and synaptic complexity above the molecular level.
An accurate replica of an NCC is therefore required in order to generate reduced models that retain critical functions and computational capabilities, which can be duplicated and interconnected to form neocortical brain regions. Knowledge of the NCC architecture can be transferred to facilitate reconstruction of sub cortical brain regions. A Foundation For Molecular Modelling Of Brain Function An accurate cellular replica of the neocortical column will provide the rst and essential step to a gradual increase in Computational power needs to increase about 1-millionfold before we will be able to simulate the human brain, with billion neurons, at the same level of detail as the Blue Column.
Algorithmic and simulation efficiency which ensure that all possible FLOPS are exploited could reduce this requirement by two to three orders of magnitude.
Simulating the NCC could also act as a test-bed to rene algorithms required to simulate brain function, which can be used to produce eld programmable gate array FPGA -based chips.
FPGAs could increase computational speeds by as much as two orders of magnitude. It could therefore be possible, in principle, to simulate the human brain even with current technology. The computer industry is facing what is known as a discontinuity, with increasing processor speed leading to unacceptably high power consumption and heat production. This is pushing a qualitatively new transition in the types of processor to be used in future computers.
These advances in computing should begin to make genetic- and molecular-level simulations possible. Experimental results that provide the elementary building blocks of the microcircuit are stored in a database. Before three-dimensional neurons are modelled electrically, the morphology is parsed for errors, and for repair of arborizations damaged during slice preparation.
The morphological statistics for a class of neurons are used to clone multiple copies of neurons to generate the full morphological diversity and the thousands of neurons required in the simulation.
A circuit builder is used to place neurons within a threedimensional column, to perform axo-dendritic collisions and, using structural and functional statistics of synaptic connectivity, to convert a fraction of axo-dendritic touches into synapses. The circuit conguration is read by NEURON, which calls up each modelled neuron and inserts the several thousand synapses onto appropriate cellular locations. The circuit can be inserted into a brain region using the brain builder.
A molecular level model of the NCC will provide the substrate for interfacing gene expression with the network structure and function. The NCC lies at the interface between the genes and complex cognitive functions. Establishing this link will allow predictions of the cognitive consequences of genetic disorders and allow reverse engineering of cognitive decit to determine the genetic and molecular causes.
This level of simulation will become a reality with the most advanced phase of Blue Gene development. The data set does not need to be complete before such a phase can begin. Indeed, it is essential to guide reductionist research into the deeper facets of brain structure and function. As a complement to experimental research, it offers rapid assessment of the probable effect of a new nding on preexisting knowledge, which can no longer be managed completely by any one researcher.
Detailed models will probably become the nal form of databases that are used to organize all knowledge of the brain and allow hypothesis testing, rapid diagnoses of brain malfunction, as well as development of treatments for neurological disorders.
In short, we can hope to learn a great deal about brain function and disfunction from accurate models of the brain. The time taken to build detailed models of the brain depends on the level of detail that is captured. Indeed, the rst version of the Blue Column, which has 10, neurons, has already been built and simulated; it is the renement of the detailed properties and calibration of the circuit that takes time.
A model of the entire brain at the cellular level will probably take the next decade. There is no fundamental obstacle to modelling the brain and it is therefore likely that we will have detailed models of mammalian brains, including that of man, in the near future.
Blue Brain IEEE
Even if overestimated by a decade or two, this is still just a blink of an eye in relation to the evolution of human civilization. As with Deep Blue, Blue Brain will allow us to challenge the foundations of our understanding of intelligence and generate new theories of consciousness. These observations are translated into mathematical algorithms which describe the form. The neurons are typed by morphology i.
The nerve impulses travel through the olfactory tract.
This actionof getting informationfrom your surrounding environment is called sensory inputbecause we are putting things inyour brain by way of your senses.
The retina is at the back of the eye ball where rods and cones structure along with other cellsand tissues covert the image into nerve impulses which are transmitted along the optic nerveto the brain where it is kept for memory. In this snail like structure. This is how we can refer the taste of one kind of food to another. Upon receiving the message.
BLUE BRAIN in IEEE FORMAT.doc
Data acquisition involves taking brain slices. The simulations show approximately linear scaling. Different types of neuron have different mixes of channels and this contributes to differences in their electrical 7. The software continues to be under active development and. The results of this work are publicly available online at Channelpedia. Carbon nanotube-coated electrodes can be used to improve recording.
It enables twelve living neurons to be concurrently patched and their electrical activity recorded. Michael Hines and the BBP team collaborated in to port the package to the massively parallel Blue Gene supercomputer. The tissue is stained with biocytin and viewed through a bright field microscope. Neuronal 3D morphologies are then reconstructed using the Neurolucidasoftware package pictured below.
It is written in C. So one second of simulated time takes about five minutes to complete.
The electrophysiological behaviour of neurons is studied using a 12 patch clamp instrument pictured below left. It is free and open source software. The Nomarski microscope enhances the contrast of the unstained samples of living neural tissue. Over genes are known to be associated with voltage-gated ion channels in the rat. This tool was developed for the Blue Brain Project and it forms a foundation of the research.
The genes for these channels are cloned at the lab. Software Development Kit is a set of software classes APIs that allows researchers to utilize and inspect models and simulations.
The ultimate aim is to be able to understand and reproduce human consciousness. A rat cortical column has about RTNeuron is ad-hoc software written specifically for neural simulations. Every single protein is simulated.
Currently the primary goal is biological validity rather than performance. The patterns of emergent behaviour are viewed with visualisation software. A basic unit of the cerebral cortex is the cortical column. A real life rat has about Workflow The simulation step involves synthesising virtual cells using the algorithms that were found to describe real neurons.
The simulations reproduce observations that are seen in living neurons. Then the cells are connected together according to the rules that have been found experimentally.
The software was developed internally by the BBP team. The animations can be stopped. Emergent properties are seen that require larger and larger networks. The algorthims and parameters are adjusted for the age. The latest simulations. Each column can be mapped to one function. Once it's understood which factors are biologically important for a given effect it might be possible to trim components that don't contibute in order to improve performance.
The simulation timestep for the numerical integrations is 0. First a network skeleton is built from all the different kinds of synthesised neurons.
The plan is to 8. Every two weeks a column model is run. The image right was rendered in RTNeuron. There are also plans to couple the brain simulations to avatars living in a virtual environment.
Blue Brain: D.stalin S. Venkatesh
This allows researchers to watch as activation potentials propogate through a neuron and between neurons. Techniques are being developed for multiscale simulation whereby active parts of the brain are simulated in great detail while quiescent parts are not so detailed. Finally the neurons are functionalised and the simulation brought to life. The visualisations are multi-scale. GPFS parallel file system Operating system: A research paper published by the BBP team in describes the following setup: Silicon Graphics The computer is used by a number of different research groups.
It has since dropped out of the top The IBM press release did not disclose the terms of the deal.This leads to a peak performance of 5. In Blue Brain cellular level models, the representation of the detailed electrophysioloy and communication of a single can require as many as 20, differential equations. The circuit can be inserted into a brain region using the brain builder. Biological data at different —omics levels displays complex cross-level structures and dependencies.
The only serious threats raised are also overcome as we note the combination of biological and digital technologies. Establishing this link will allow predictions of the cognitive consequences of genetic disorders and allow reverse engi-neering of cognitive deficits to determine the genetic and molecular causes. Shady Mahmoud. Each application or component is composed of a steadily expanding set of sub-components e.
Indeed, the rst version of the Blue Column, which has 10, neurons, has already been built and simulated; it is the renement of the detailed properties and calibration of the circuit that takes time.